March 24, 2019
Many studies have referred specifically to AD, and in this review the terms atopic dermatitis and eczema are considered interchangeable. AD is a common chronic pruritic skin disease seen in infants and children. In the International Study of Asthma and Allergies in Childhood (ISAAC), among the 56 countries, the prevalence of AD in children varied significantly from 0.3% to 20.5% but shows consistent trends in increasing disease prevalence over time. In a population based study in the US, the prevalence of AD among children 5 to 9 years old is estimated at 17.2%. AD starts early in the first few years in life. Of the affected children, 45% of them had the condition during the first 6 months of life, 60% during the first year of life and up to 85% suffered AD before 5 years of age.Less than half of the patients with AD have complete resolution by 7 years of age and only 60% of them have resolution by adulthood, indicating the chronic nature of AD.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062798/The research points to sensitisation to allergens due to a dysfunctional skin barrierDual Factors May Be Necessary for Development of Atopic March in Early Infancy.The incidence of atopic diseases, including atopic dermatitis (AD), food allergies, allergic rhinitis, and asthma, has increased in recent decades, and currently affects approximately 20% of the population. Atopic march is the development of AD in infancy and subsequent food allergies, allergic rhinitis, and asthma in later childhood. Patients with infantile eczema may develop typical symptoms of AD, allergic rhinitis, and asthma at certain ages. Some patients' symptoms persist for several years, whereas others may have resolution with aging. Development of these diseases is strongly influenced by the following two factors: skin dysfunction caused by filaggrin mutations and development of colonization of microflora in early infancy. Filaggrin mutations predisposing to asthma, allergic rhinitis, and allergic sensitization, only in the presence of AD, strongly support the role of filaggrin in the pathogenesis of AD and in subsequent progression of the atopic march. Several studies have shown that development of colonization of microflora in early infancy might affect development of allergic disease or food desensitization. Therefore, massive allergen exposure to genetic skin dysfunction in early infancy and an imbalance of microflora might be necessary for development of atopic march.https://www.ncbi.nlm.nih.gov/pubmed/29540642We therefore highly recommend using our ViSTa Spa Tablets if you are bathing a young child or if you know someone who has young children please share this information with them.
May 01, 2019